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Update on Biomarker-Driven Targeted Therapies in Advanced Urothelial Carcinoma


March 11, 2021
Live-Virtual Satellite Symposium



 
  Name*


 
 
Select Profession*
 
 



 
   
     
   
   
 

Post-Test

 
 
1. In a 64-year old woman with a 3 cm bladder cancer that was completely resected with no residual cancer or carcinoma situ, the next step in her management should be:*




 
 
2. In the Keynote 057 clinical trial in patients with BCG-unresponsive non-muscle invasive bladder cancer, treatment with pembrolizumab resulted in all the following EXCEPT:*




 
 
3. In the Phase 3 CheckMate 274 trial of adjuvant nivolumab versus placebo in patients who underwent radical surgery for high-risk muscle-invasive urothelial carcinoma, nivolumab significantly improved progression-free survival *




 
 
4. The JAVELIN Bladder 100 clinical trial assessed first-line maintenance therapy with avelumab in patients with advanced urothelial cancer whose disease has not progressed with platinum-based induction chemotherapy. The following is true about the results of the trial*




 
 
5. The PROOF 302 trial with infigratinib as adjuvant therapy in invasive urothelial carcinoma is being tested in patients with which of the following molecular biomarkers:*




 
 
6. Which of the following biomarkers are associated with platinum sensitivity in advanced UC?*




 
 
7. Patients with locally advanced or metastatic urothelial carcinoma treated with the pan-FGFR inhibitor erdafitinib demonstrated*




 
 
8. The most commonly-reported adverse event with FGFR inhibitors like erdafitinib is*




 
 
9. The global, open-label phase III EV-301 trial evaluated enfortumab vedotin (EV) vs chemotherapy in patients with advanced or metastatic urothelial carcinoma who had received a prior platinum-containing chemotherapy and had disease progression during or after PD-1/L1 inhibitor treatment. Compared to chemotherapy, patients treated with EV demonstrated significantly improved*




 
   
   
   
 

Evaluation

 
 
As a result of my participation in this activity, I am better able to:*
  Strongly Agree Agree Disagree Strongly Disagree
Describe the epidemiology of urothelial carcinoma
Discuss the unmet clinical needs in the current standard of care in advanced urothelial carcinoma
Describe the molecular pathways that may be altered in urothelial carcinoma, and the role of biomarker testing in selecting patients for targeted therapies
Define the efficacy and safety/tolerability of targeted therapies in patients with advanced urothelial carcinoma and how to select patients for these therapies
 
 
The activity was appropriate and met my educational needs.*




 
 
The following speaker(s) demonstrated experiential knowledge of the topic.*
  Excellent Good Fair Poor
Arlene Siefker-Radtke, MD (Chair)
Gopa Iyer, MD
Seth Lerner, MD
Sumanta Pal, MD
 
 
Please indicate the extent of your agreement with the following statements:*
  Strongly Agree Agree Disagree Strongly Disagree
The educational materials were effective.
The faculty was knowledgeable, effective and free of bias.
The learning activities were effective and incorporated active learning methods.
The content provided a fair and balanced coverage of the topic.
 
 
The content was objective, current, scientifically sound and free of commercial bias.*
 
   
 
Based on information presented in the activity, I will:*







 
 
As a result of this course, I will likely make changes to my practice in these categories:*






 
   
   
   
   
   
 
I attest that I have completed this entire CE activity*

 
   
   
   

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